On-line Karyotype

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Library Assignment-Karyotypes                                                      Name __________________

                                                                                                            Partner ______________

Follow the instructions to construct three different karyotypes, determine the karyotype, and give the condition that results from having this karyotype.  Write your answers in the spaces provided on this page.

You will then review karyotyping and look at a new way to karyotype that has some advantages over the clasical technique.  Read about the karyotype technique, and answer the questions in the space provided.

To get to the URL site:

            Go to Mrs. H’s web page.  Click on links > mitosis/meiosis >scroll to karyotyping, click on “making a karyotype”.

 Do the interactive activity in the sidebar “Matching up chromosomes in a karyotype”.  The answer to the question is: _____________ because:

NEXT:

Go back to the website, and click on the next activity, “online activity web karyotyping”.

What to do:

            Check off the steps as you do them so that you are sure you complete everything.

            ___ Read the introduction,

            ___ click on “patient histories”.  Read the history of Patient A,

            ___ then click on “Complete Patient A’s Karyotype”.

___ when you are done, be sure to fill in these answers.  Then go to patients B and C and repeat the procedure for them.

Patient A karyotype: _______________________ (put the # of chromosomes present, comma, the sex chromosomes, comma, + or – the abnormal chromosome..if the sex chromosomes are abnormal, do not do this last part, just write what the sex chromosomes are)

Diagnosis:

Description of condition:

Patient B karyotype: _______________________

Diagnosis:

Description of condition:

Patient C karyotype: _______________________

Diagnosis:

Description of condition:

NEXT:

For your next URL, go back to Mrs. H’s website and click the next activity down...”Spectral Karyotyping”.

            ___read about spectral karyotyping for a general overview,

            ___then click on “methods” and then “applications” to read to find out more.

            ___Answer the questions in the space below.  Use complete sentences.

1. What is the difference between classical karyotyping and spectral karyotyping?

2. What are the advantages of spectral karyotyping over classical karyotyping?

3. What are some examples of the way that spectral karyotyping is being used?

4. What did you think was most interesting about this new method of karyotyping?

NEXT:

Go to the next link “what you can’t find out” to see what is difficult to determine, even with spectral karyotyping.  You will find them in the sidebar.  List three things on the next page....

1.

2.

3.

NEXT:

Go to the last link on the website to go to the last activity “genetic disorders”.

1. What are the four types of genetic disorders/describe them/give examples in the table below.

Read the sidebars on the page.

2. Why don’t all mutations cause disorders?

3. How do viruses affect your DNA?

4. Describe the symptoms of a disease caused by one of the examples you gave in the table above that was not one of the diseases investigated earlier.  You can get to some of them by links off this page.

If you finish early and there is still time in the bell, head back to http://gslc.genetics.utah.edu/units/disorders/karyotype/karyotypeinfo.cfm (4th link down), and scroll down to the third sidebar to “test your knowledge” and take the quiz.  Let me know how you do!

© Mariemont City Schools 2002, Halsall (12/28/05 )